Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources. Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles. Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals. Explores recent internet trends, web-based databases, and software tools in a section on the online environment. Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents. Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field.
The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was published just prior to the terrorist attacks of September 11, 2001. The second edition titled, Chemical Warfare Agents: Pharmacology, Toxicology, and Therapeutics, included new epidemiological and clinical studies of exposed or potentially exposed populations; new treatment concepts and products; improved organization of the national response apparatus addressing the potential for CWA terrorism; and improved diagnostic tests that enable rapid diagnosis and treatment. Since the second edition, the chemical warfare agent community has worked hard to advance research for protection and treatment and develop/improve response approaches for individuals and definitive care. Consequently, in addition to updating previous chapters, Chemical Warfare Agents: Biomedical and Psychological Effects, Medical Countermeasures, and Emergency Response, Third Edition features several new chapters that address the Syrian War, chemical destruction, the Organisation for the Prohibition of Chemical Weapons, biomarkers for chemical warfare agent exposure, field sensors, aircraft decontamination, lung/human on a chip, chemical warfare response decision making, and other research advancements. Features: Describes the newest medical interventions, and the latest technologies deployed in the field, as well as developments in the international response to CW usage highlighting recent events in the Middle East Discusses the latest in organizational/interagency partitioning in terms of responsibilities for emergency response, not just in the United States but at the international level—whether prevention, mitigation, medical care, reclamation, or medico-legal aspects of such response Contains the most current research from bench-level experts The third edition contains the most up-to-date and comprehensive coverage of the question of chemical warfare agent employment on the battlefield or in terrorism. Edited by workers that have been in the field for 35+ years, it remains faithful to the scientific "constants," while evaluating and crediting the advances by the industry that have made us safer.
Loomis's Essentials of Toxicology, Fifth Edition, provides the information on the harmful biologic effects associated with exposures to chemicals of all types. The scope of this book includes a discussion of the major types of chemicals involved, their general properties and detrimental biologic effects, the methods used to demonstrate these effects, the basis for clinical diagnosis, and therapy for the harmful effects of chemicals on humans. Individual examples are used to demonstrate the principle discussed. This reference volume will be an invaluable resource for both toxicologists and graduate and advanced undergraduate students in toxicology and public health. Provides a revised and updated edition of one of the "gold" works in the field Includes both principles and methods Requires minimal background in chemistry and biology Expanded Information Sources in Toxicology
Shelving Guide; Environmental Science This is a groundbreaking and innovative book now in its fourth edition. The first edition won the CHOICE award for outstanding Academic Book while editions two and three became bestsellers on their own right. This fourth edition is packed with new updates on current world events associated with environmental issues and related health concerns. The author maintains traditional concepts and merges them with new and controversial issues. The book has been revised to include up-to-date topics with and a revised Web site with updated links. So what Coverage of emergency preparedness for environmental health practitioners Discussion of population dynamics especially with regard to overpopulation and underpopulation around the world and their respective influences on social, economic, and environmental concerns. The mechanisms of environmental disease, emphasizing genetic disease and its role in developmental disorders and cancer. Human behaviors and pollution are presented along with respect to their roles in cancer risk. The ever increasing issues surrounding emerging and re-emerging diseases around the earth and the introduction of an increasing number of emerging diseases. The growing problems of asthma and other health effects associated with air pollution. An exploration of the mechanisms of toxicity with special reference to the immune system and endocrine disruption. The ongoing issues of the creation and disposal of hazardous waste along with the controversies surrounding disposal are presented. The issues and benefits of recycling are explored. The use of HACCP in assuring food quality, food safety issues, and the Food Quality Protection Act are discussed. Numerous technical illustrations, charts, graphs, and photographs are included What on the Web? Test bank and study questions giving a complete review of the concepts covered. Search tools for online journals and databases covering useful, up-to-date information in health and environmental topics Subject specific links by chapter as well as Federal, state, and organization sites with relevant information Downloadable PowerPoint files for each Chapter providing the instructor with ready-made presentation materials that can be modified as needed. Downloadable and printable test questions and answers for each chapter available to instructors
Risk analysis is not a narrowly defined set of applications. Rather, it is widely used to assess and manage a plethora of hazards that threaten dire implications. However, too few people actually understand what risk analysis can help us accomplish and, even among experts, knowledge is often limited to one or two applications. Explaining Risk Analysis frames risk analysis as a holistic planning process aimed at making better risk-informed decisions and emphasizing the connections between the parts. This framework requires an understanding of basic terms, including explanations of why there is no universal agreement about what risk means, much less risk assessment, risk management and risk analysis. Drawing on a wide range of case studies, the book illustrates the ways in which risk analysis can help lead to better decisions in a variety of scenarios, including the destruction of chemical weapons, management of nuclear waste and the response to passenger rail threats. The book demonstrates how the risk analysis process and the data, models and processes used in risk analysis will clarify, rather than obfuscate, decision-makers’ options. This book will be of great interest to students and scholars of risk assessment, risk management, public health, environmental science, environmental economics and environmental psychology.
This practical book provides toxicologists with essential information on the regulations that govern their jobs and products. Regulatory Toxicology, Third Edition is an up-to-date guide to required safety assessment for the entire range of man-made marketed products. Individual chapters written by experts with extensive experience in the field address requirements not only for human pharmaceuticals and medical devices (for which there are available guidances), but for the full range of man-made products. New in this edition are three chapters addressing Safety Data Sheet Preparation, Regulatory Requirements for GMOs, and Regulatory Requirements for Tobacco and Marijuana. The major administrative divisions for regulatory agencies and their main responsibilities are also detailed, as are the basic filing documents the agencies require. Coverage includes food additives, dietary supplements, cosmetics, over-the-counter drugs, personal care and consumer products, agriculture and GMO products, industrial chemicals, air and drinking water regulations and the special cases of California’s Proposition 65, requirements for safety data sheets, and oversight regulations. Both US and international requirements are clearly presented and referenced. In one volume, those who have regulatory responsibility in companies, lawyers, educators, and those selling these materials in the marketplace can learn about regulatory requirements and how to meet them.
This issue of Veterinary Clinics: Small Animal Practice is a comprehensive update on Common Toxicologic Issues in Small Animals, edited by Dr. Stephen B. Hooser and Dr. Safdar A. Khan. The issue includes updated articles first published in the 2012 issue, including: Animal Poisoning Case Trends in the US; Investigative Diagnostic Toxicology and the Role of the Veterinarian in Pet Food-Related Outbreaks; Pet Food Recalls and Contaminants; Use of Intravenous Lipid Emulsions for Treating Certain Poisoning Cases; Calcium Channel Blocker Toxicity in Dogs and Cats; Management of Attention-Deficit Disorder and Attention-Deficit/Hyperactivity Disorder Drug Intoxication in Dogs and Cats; Toxicology of Frequently Encountered Nonsteroidal Anti-Inflammatory Drugs in Dogs and Cats; Xylitol Toxicosis in Dogs; Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats; Toxicology of Newer Insecticides; Common Rodenticide Toxicoses; Mushroom Poisoning Cases in Dogs and Cats: Diagnosis and Treatment of Hepatotoxic, Neurotoxic, Gastroenterotoxic, Nephrotoxic, and Muscarinic Mushrooms; Differential Diagnosis of Common Acute Toxicologic Versus Nontoxicologic Illness; Common Reversal Agents/Antidotes in Small Animal Poisoning; and two new articles on the Toxicity of Marijuana & Synthetic Marijuana, and Radiation Emergencies.
The gastrointestinal tract is the most important of the three major routes of entry (and clearance) of xenobiotics and biologic entities into the bodies of mammals. As such, it is also the major route for administration of pharmaceuticals to humans. Gastrointestinal Toxicology, Second Edition describes the mechanism for entry and clearance of xenobiotics, as well as the barriers, immunologic and metabolic issues, and functions present in the GI tract. Appearing in this volume are also considerations of the microbiome and its actions and influence on the function of the GI tract and on the toxicity and pharmacodynamics of ingested substances (including nutrients, toxins, and therapeutics). These fifteen chapters written by experienced experts in the field address methods to evaluate GI function; specifics of GI function and toxicity assessment in canines and minipigs; classes of compounds with their toxicity; species differences; and the toxicity (and promise) of nanoparticles. Those needing to understand the structure, function, and methods of studying the GI tract will find this volume a singular source of reference.
This book provides a concise, yet comprehensive overview of the many facets relating to human health risk assessments in relation to chemical exposure problems. It presents some very important tools and methodologies that can be used to address chemical exposure and public health risk management problems in a consistent, efficient, and cost-effective manner. On the whole, the book represents a collection and synthesis of the principal elements of the risk assessment process that may be used to more effectively address issues pertaining to human exposures to chemicals found in modern societies. This also includes an elaboration of pertinent risk assessment concepts and techniques/methodologies for performing human health risk assessments. Written for both the novice and the experienced, the subject matter of this book is an attempt at offering a simplified and systematic presentation of public health risk assessment methods and application tools – all these facilitated by a layout that will carefully navigate the user through the major processes involved. A number of illustrative example problems are interspersed throughout the book, in order to help present the book in an easy-to-follow, pragmatic manner.
As with the previous editions, Introduction to Toxicology, Fourth Edition, continues to chart the evolution of the field of toxicology, from the use of natural toxins by ancient tribes through the developments established by Paracelsus, and progresses through to the current topics in the public interest. For centuries, the study of toxicology has fascinated students. The book begins with basic toxicological principles, including an historical summary, dose-response relationships (NEW chapter), exposure-response relationships (NEW chapter), disposition, and metabolism of xenobiotic toxic substances. Other important new chapters include target organ toxicity, toxicity of carcinogenic agents and new and updated concepts in toxicity testing, and antidotes and treatment of poisonings. In all, nine new or expanded chapters from the third edition are advanced. Current concerns about the effects of therapeutic drugs, carcinogens, industrial toxins, pesticides, and herbicides on human health, animal welfare, and the stability and maintenance of the ecosystem continue to highlight toxicology as an important and growing scientific discipline. Key features: Comprehensive coverage of the field of toxicology which illustrates its importance to and impact on society Uses pertinent examples, tables, and diagrams to aid understanding with learning objectives, summaries, questions, and answers for each chapter Clearly and concisely written and presented concepts for easy comprehension by toxicology, biomedical, and health science students Examines the complex interactions associated with toxicological events Covers the effect of toxins on biological and physiological systems This book successfully condenses the diffuse literature in the field into an accessible and readable text, made easier with the insertion of many tables and figures. It introduces fundamental concepts and builds upon these using topical and relevant historical examples. Its improved format includes learning objectives and summaries of each chapter, as well as questions and answers suitable for self-assessment. This latest edition is an invaluable resource for undergraduate and graduate toxicology students, as well as an introductory text for other health care students and professionals. The book also functions as a comprehensive introductory reference text for environmental scientists, medical biologists and chemists, chemical engineers, and regulatory agencies, with interests in toxicologically related areas.
Chemical Food Safety: A Scientist's Perspective introduces readers to the science of risk assessment as applied to food safety and offers relevant, current information on research and statistics, chemicals, biotechnology issues, and emerging diseases that challenge the risk assessment strategies of toxicology and microbiology. Riviere investigates the potential health consequences of pesticides, food additives and drugs, demonstrating how science can be applied to make risk assessments. He differentiates between “real risks” and “phantom risks,” unearthing numerous fallacies in the public perception of risk assessment and evidence of people’s intolerance to certain types of risks—no matter how remote. Chemical Food Safety is based on credible, scientifically correct data rather than irrational fears propagated by media coverage concerning food safety. The book explores these riveting topics: *food security and the world of bioterrorism, *toxicity of natural compounds and artificial additives in foods, *the toxicology of pesticides in food, *issues of biotechnology and genetically modified food, *other compelling issues in chemical food safety.With its focus on how the results of toxicology are applied in the real world, Chemical Food Safety: A Scientist’s Perspective will be a valuable addition to the libraries of food scientists, dieticians, animal producers, veterinarians and anyone else with a professional or personal interest in risk assessment, toxicology, epidemiology or food safety.