Molecular Biological Markers for Toxicology and Risk Assessment

Medical / By /
Molecular Biological Markers for Toxicology and Risk Assessment

Author: Bruce A. Fowler

Publisher: Academic Press

ISBN: 9780128019016

Category: Medical

Page: 164

View: 517

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Computational Toxicology

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Computational Toxicology

Author: Hong Fang

Publisher: Elsevier Inc. Chapters

ISBN: 9780128060520

Category: Medical

Page: 274

View: 800

Current advances in genomics, proteomics, and metabolomics are widely anticipated to translate in the future to a constellation of benefits in human health. However, few biomarkers for risk assessment using “omics” technologies have been reported in the last decade. Nevertheless, the potential application for omics technologies is tremendous. The use of biomarker-based monitoring approaches as a tool for environmental risk assessment is often critically limited by a lack of integrated bioinformatics approaches, statistical analyses, and predictive models. In this chapter we discuss the key steps for omics biomarker discovery and also present the use of the decision forest (DF) classification method as an example with specific application to microarray gene expression data, proteomics, and SNP genotypic data. An integrated bioinformatics approach with the correct choice of samples, omics technologies, and statistical techniques will allow the development of powerful new biomarkers for safety assessment.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Nature / By /
Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author: National Research Council

Publisher: National Academies Press

ISBN: 9780309070867

Category: Nature

Page: 348

View: 849

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Computational Toxicology

Computers / By /
Computational Toxicology

Author: Bruce A. Fowler

Publisher: Academic Press

ISBN: 9780123965080

Category: Computers

Page: 274

View: 577

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared

Drug Discovery Toxicology

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Drug Discovery Toxicology

Author: Yvonne Will

Publisher: John Wiley & Sons

ISBN: 9781119053330

Category: Medical

Page: 598

View: 137

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Risk Assessment for Human Metal Exposures

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Risk Assessment for Human Metal Exposures

Author: Gunnar F. Nordberg

Publisher: Academic Press

ISBN: 9780128042687

Category: Medical

Page: 348

View: 761

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication—the classic risk assessment paradigm—with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment. Covers fundamental risk assessment concerns for the effects of metals on human health Provides an easy-to-use structure to quickly locate specific methods Uses case studies to illustrate the methods and theories described Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health

Biological Concepts and Techniques in Toxicology

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Biological Concepts and Techniques in Toxicology

Author: Jim E. Riviere

Publisher: CRC Press

ISBN: 9781420018448

Category: Medical

Page: 416

View: 550

Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol

Toxicity-Pathway-Based Risk Assessment

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Toxicity-Pathway-Based Risk Assessment

Author: National Research Council

Publisher: National Academies Press

ISBN: 0309156920

Category: Nature

Page: 134

View: 691

In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.

Genetic Toxicology and Cancer Risk Assessment

Medical / By /
Genetic Toxicology and Cancer Risk Assessment

Author: Wai Nang Choy

Publisher: CRC Press

ISBN: 9780824745226

Category: Medical

Page: 405

View: 565

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Advances in Toxicology and Risk Assessment of Nanomaterials and Emerging Contaminants

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Advances in Toxicology and Risk Assessment of Nanomaterials and Emerging Contaminants

Author: Liang-Hong Guo

Publisher: Springer Nature

ISBN: 9789811691164

Category: Medical

Page: 375

View: 217

This book details the state-of-the-art methodological advances for delineating the toxicology and working mechanisms of nanomaterials, microplastics, fine aerosol particulates (PM2.5) as well as emerging organic pollutants. It also provides latest computational approaches for toxicity prediction and risk assessment of nanoscale materials which possess realistic chances to enter the environment and human organism. Written by leading scientists at the frontiers of environmental science and nanomedicine, this book is intended for both young researchers and experienced professionals working in the fields of environmental protection, human health and occupational safety, nanotechnology, material science and nanomedicine, as well as graduate students majoring in environmental and health sciences.

Molecular, Clinical and Environmental Toxicology

Medical / By /
Molecular, Clinical and Environmental Toxicology

Author: Andreas Luch

Publisher: Springer Science & Business Media

ISBN: 9783764383404

Category: Medical

Page: 574

View: 370

Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Handbook on the Toxicology of Metals

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Handbook on the Toxicology of Metals

Author: Gunnar F. Nordberg

Publisher: Academic Press

ISBN: 9780123973399

Category: Medical

Page: 1542

View: 936

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium