The application of evidence-based veterinary medicine (EBVM) can assist in improving and optimising the diagnosis, prognosis, control, treatment and ultimately the welfare of animals. It can also provide the user with a methodology for appropriate, patient orientated life-long, self-directed, learning. To practise evidence-based veterinary medicine we require a range of skills that we may not have. This book will explain what evidence-based veterinary medicine is and show how it can be applied to veterinary practice to improve the quality of care for patients and provide informed choices for owners. It will provide the reader with a toolkit of skills necessary to practise evidence-based veterinary medicine. The authors explain how to: · Transform information needs into a series of clinical questions that can be answered · Search for best available external evidence · Critically appraise the evidence for its validity and importance · Apply the results in clinical practice · Understand the process of diagnosis and use of clinical diagnostic decision support systems · Perform a decision analysis This book is aimed at practitioners but will be of interest to veterinary surgeons at any stage of their training or career wishing to learn about EBVM. The authors are responsible for devising and teaching an EBVM course at the veterinary school at Cambridge. Dr Peter Cockcroft, Clinical lecturer, Department of Clinical Veterinary Medicine, University of Cambridge.
"Uveal melanoma is the most common primary malignant intraocular tumor in adults. The management of uveal melanoma remains a clinical dilemma, which reflects our poor understanding of this life-threatening disease. A major challenge facing researchers investigating this malignancy has been to develop a suitable animal model. The purpose of this work is to characterize, in detail, the processes of tumor development, malignant cell dissemination and metastasis in a 10-week albino rabbit model of uveal melanoma. Intraocular tumors successfully developed, and metastatic disease was present in all animals at the end of the experiment. For the first time using an animal model of uveal melanoma, the presence of circulating malignant cells in the bloodstream was demonstrated. Knowledge gained from this study has led to a better overall understanding of the progression of the disease in this experimental model and may facilitate the development of methods for the prevention, early detection and treatment of metastatic uveal melanoma." --
Ocular Immunology in Health and Disease is designed to provide the reader with a review of the basic concepts in immunology. A thorough introductory section is followed by a discussion of the unique attributes of ocular immunity and the basis of ocular immune privilege. * - Provides a basic introduction to immunology for the student and practitioner * - Detailed and thorough introduction and discussion included in each chapter * - Describes unique attributes of ocular immunity and the basis of ocular immune privilege